Results
| PMID | 18295214 |
| Gene Name | IL18 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 105 |
| Population details | 105 (72 endometriosis patients, 33 controls) |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | IL-12, IL-18 |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2009 Feb;91(2):320-4. doi: 10.1016/j.fertnstert.2007.11.060. Epub Fairbanks, Flavia| Abrao, Mauricio S| Podgaec, Sergio| Dias, Joao Antonio Jr| de Oliveira, Ricardo M| Rizzo, Luiz Vicente Endometriosis Unit, Gynecological Clinic, Sao Paulo University School of Medicine, Sao Paulo, SP, Brazil. OBJECTIVE: To evaluate interleukin (IL)-12 and IL-18 levels in the serum and peritoneal fluid of women with and without endometriosis. DESIGN: Cross-sectional survey. SETTING: University hospital. PATIENTS: Interleukin-12 and IL-18 levels were compared in 105 patients submitted to laparoscopy because of symptoms suggestive of endometriosis (pain and/or infertility). The disease was confirmed in 72 patients (study group), while in 33 patients findings were not compatible with endometriosis (control group). INTEVENTION(S): Blood sample and peritoneal fluid were obtained from patients during videolaparoscopy. MAIN OUTCOME MEASURE(S): The levels of IL-12 and IL-18 in peripheral blood and peritoneal fluid were determined and compared with the stage and site of the disease and histologic classification. RESULT(S): IL-12 levels measured in peritoneal fluid were higher in patients with endometriosis compared with the control group. A significant increase in IL-12 levels was found when the more advanced stages of the disease were compared with the initial stages. No statistically significant differences were found in IL-18 levels, either in serum or in peritoneal fluid samples. CONCLUSION(S): Patients with severe endometriosis have higher IL-12 levels irrespective of IL-18 levels, suggesting that in this disease an alternative pathway is involved in induction of the Th1 immune response. Mesh Terms: Adolescent| Adult| Ascitic Fluid/*immunology| Biomarkers/analysis| Case-Control Studies| Cross-Sectional Studies| Endometriosis/*immunology/pathology| Female| Humans| Interleukin-12/*analysis/blood| Interleukin-18/*analysis/blood| Laparoscopy| |
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